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- What: ESL Pro League CS:GO Season 21
- Where: ESL Studio in Stockholm, Sweden
- Date: March 1 – March 16, 2025
- How to Watch: Twitch, YouTube
Twenty-four of the best CS:GO teams in the world head to Stockholm, Sweden, in March to play in the ESL Pro League Season 21 CS:GO event. The event begins on March 1 and ends on March 16. Up for grabs is a prize pool of $400,000. The winning team takes home the lion’s share of that amount, $100,000. The victory also counts towards the Intel Grand Slam, which awards $1,000,000 to the first team that wins four ESL-sponsored events. Natus Vincere and Team Vitality, who are among the betting favorites for Season 21 of the ESL Pro League, each have two wins.
The format of Season 21 of the ESL Pro League sees 16 invited teams compete in a Swiss stage format featuring best-of-three matches. The top eight teams in the Swiss stage move on to Stage 2 where they join the eight teams who earned spots there via the VRS standings. Stage 2 will have the same format as Stage 1. The top eight teams then move to the Playoffs, which will be contested in a single-elimination bracket starting on March 13th. The quarterfinals and semifinals are best-of-three, while the Grand Final is best-of-five. The Grand Final goes down on March 16.
Before we look at the betting breakdown for the ESL Pro League CS:GO Season 21, check out the best sites for betting on CS:GO esports events, and while you’re at it, take a look at the best sports betting apps and mobile options.
ESL Pro League Season 21 betting picks
| To Win ESL Pro League Season 21 |  |  |  |
| Team Spirit | +250 | +250 | +250 |
| Team Vitality | +275 | +275 | +275 |
| Natus VIncere | +500 | +500 | +500 |
| Eternal Fire | +700 | +700 | +700 |
| G2 Esports | +700 | +700 | +700 |
| The MongolZ | +750 | +750 | +750 |
| MOUZ | +1000 | +1000 | +1000 |
| Team Liquid | +1600 | +1600 | +1600 |
| Falcons | +1600 | +1600 | +1600 |
| HEROIC | +2500 | +2500 | +2500 |
| FURIA | +3300 | +3300 | +3300 |
| paiN Gaming | +4000 | +4000 | +4000 |
| 3DMAX | +5000 | +5000 | +5000 |
| Gamer Legion | +5000 | +5000 | +5000 |
| MIBR | +6600 | +6600 | +6600 |
| M80 | +10000 | +10000 | +10000 |
| SAW | +15000 | +15000 | +15000 |
| Nemiga | +15000 | +15000 | +15000 |
| FlyQuest | +25000 | +25000 | +25000 |
| NRG | +25000 | +25000 | +25000 |
| Lynn Vision | +50000 | +50000 | +50000 |
| TYLOO | +100000 | +100000 | +100000 |
| Mindfreak | +150000 | +150000 | +150000 |
| Housbets | +250000 | +250000 | +250000 |
Team Spirit betting breakdown
Playing out of Russia, Team Spirit is one of the squads beginning their play in Stage 2. The club is currently the No. 1 ranked team in the CS:GO World Rankings, a spot Team Spirit has held since late January. The club is on a strong run over the past few months. Team Spirit wrapped up 2024 with a $500,000 win at the Perfect World Shanghai Major 2024. They then opened 2025 with a first-place finish at the BLAST Bounty Spring 2025 tournament and followed that with a runner-up spot at the IEM Katowice 2025 event.
Team Spirit has been playing together as a unit since late 2023.
Team Vitality betting breakdown
Playing out of France, Team Vitality moved to the No. 2 slot in the World Rankings in mid-February. They will look to at least hold onto that spot and maybe even regain the No. 1 ranking, which they held as recently as September 2024. Like Team Spirit, Team Vitality opens its run in this event in Stage 2.
Team Vitality placed 5th-8th at the Perfect World Shanghai Major 2024 and followed that with another 5th-8th place finish at BLAST Bounty Spring 2025. However, the club picked up $400,000 in early February with a win at the Intel Extreme Masters Katowice 2025 tournament.
The roster for Team Vitality has been together since late 2023, with the exception of ropz, who joined in early 2025.
Natus Vincere betting breakdown
Natus Vincere is one of the top CS:GO teams. Only Astralis has held the No. 1 rank longer than them. Overall, Natus Vincere has been No. 1 for 557 days, with a record run of 264 days at the top of the rankings. They fell from the top spot in January, when they dropped to No. 2. Natus Vincere is currently ranked No. 3 in the world. The team plays out of Ukraine.
Natus Vincere are looking for their first win since they placed first at the Esports World Cup 2024 in July 2024.
They had a disappointing 9th-11th place finish at the Perfect World Shanghai Major 2024 event. Following that, Natus Vincere placed 3rd-4th at BLAST Bounty Spring 2025. In their most recent outing, the team placed 3rd-4th at the Intel Extreme Masters Katowice 2025 tournament.
The club’s roster has been together since 2023. Natus Vincere also begin play at the ESL Pro League 21 in Stage 2.
Best bet to win ESL Pro League Season 21
Team Spirit has been playing at a high level as of late, and there’s no reason to believe that they cannot continue on that trajectory.
The betting pick is for Team Spirit to win ESL Pro League 21.
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