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- Detroit (9-1) is a 7.5-point road favorite over the Colts (5-6) in Week 12
- Anthony Richardson looks to build on a spectacular 3-TD performance in his return
- Sunday’s matchup kicks off from Lucas Oil Stadium in Indianapolis, IN at 1:00 pm ET
Detroit delivered the final death blow to Doug Pederson’s job prospects on Sunday, scoring a touchdown on seven straight offensive drives in a 52-6 beatdown of the Jaguars. Dan Campbell’s team will now face another AFC South club in the Colts. Indianapolis was rewarded for their decision to turn back to Anthony Richardson, who accounted for 3 TDs in a 28-27 victory over the Jets in Week 11.
Before we look at the odds for Colts vs Lions, check out the top betting sites for NFL football and the Best Super Bowl 59 Betting Sites 2024.
Colts vs Lions
 | Spread | Money Line | Total Points |
| Detroit Lions | -7.5 (-110) | -355 | Un 50.5 (-115) |
| Indianapolis Colts | +7.5 (-110) | +285 | Ov 50.5 (-105) |
Detroit domination
Jared Goff passed 412 yards and four touchdowns with a perfect 158.3 passer rating in Sunday’s 52-6 victory over Jacksonville. David Montgomery ran for 75 yards and two TDs and Jahmyr Gibbs earned 123 scrimmage yards with a score. Amon-Ra St. Brown made 11 grabs for a season-high 161 yards and two TDs and Jameson Williams raced for 124 yards and a score. In other words, we hope you had Lions players on your fantasy roster last week.
Detroit lost another key piece on defense as captain Alex Anzalone was ruled out with a forearm injury. However, trade deadline acquisition Za’Darius Smith delivered in his first start, with four QB pressures and half a sack.
Jared Goff today vs. the #Jaguars:
• 24/29
• 412 passing yards
• 4 TDs
• 0 INTs
• Perfect 158.3 rating pic.twitter.com/UTGiEGaS8Z— Ari Meirov (@MySportsUpdate) November 17, 2024
A-Rich delivers
Anthony Richardson returned strong after two weeks on the bench. The 22-year-old passed for a career-high 272 passing yards and a touchdown while adding two rushing scores in a 28-27 win over the Jets. Richardson was uncommonly accurate (66.7%) and led back-to-back TD drives with the game on the line.
After snapping a three-game losing streak, Indianapolis is still in a crowded AFC playoff race at 5-6. Detroit will provide a real test for the Colts before they head into a winnable stretch of games to close the year.
Indianapolis vs Detroit
Detroit is a 7.5-point road favorite at Lucas Oil Field and the over/under of 50.5 points is the highest on the Week 12 slate. The Lions have the top scoring offense (33.6) in the NFL, averaging 152.2 rushing yards (3rd in the NFL) and 242.5 passing yards (6th) per game.
Indianapolis’ defense is allowing opposing offenses to rack up 374.5 YPG – fifth-worst in the league. The Colts are getting gashed on the ground (143.1 YPG) and through the air (231.5). Aaron’s Glenn’s D is vulnerable to the pass (6th-worst in NFL) but No. 5 against the run (94.8 YPG allowed).
Anthony Richardson in the 4th quarter vs the Jets
🧊 8/10
🧊 129 passing yards
🧊 1 passing TD
🧊 1 rushing TD pic.twitter.com/Z0hGLTf3dt— PFF (@PFF) November 18, 2024
Best Bet
The Lions are an absolute buzzsaw right now and their defense should make it difficult for Jonathan Taylor on the ground. We like Detroit to cover (-7.5) with the UNDER 50.5 points.
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