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- San Francisco (6-7) is a 2-point home favorite over the Los Angeles Rams (7-6) in Week 15
- Niners coach Kyle Shanahan has a 10-6 career record versus former colleague Sean McVay
- Thursday Night Football kicks off from Levi’s Stadium in Santa Clara, CA at 8:20 pm ET
Matthew Stafford passed for a season-high 320 yards and two touchdowns in a thrilling 44-42 victory over the Bills on Sunday. The Rams will now head to San Francisco to face a Niners club coming off a dominant 38-13 win over Chicago. With both teams trailing the Seahawks in the NFC West, Thursday’s divisional battle could be a playoff death blow for the loser.
Before we examine the odds for 49ers vs Rams, check out the best TNF bets for Week 15 and the the top betting sites for NFL football 2024.
49ers vs Rams
 | Spread | Money Line | Total Points |
| Los Angeles Rams | +2.0 (-110) | +110 | Ov 48.5 (-110) |
| San Francisco 49ers | -2.0 (-110) | -130 | Un 48.5 (-110) |
Rams upset Bills
The Rams survived a six-touchdown day from Josh Allen to upset the Bills 44-42 in Week 14. Puka Nacua had a season-high 162 receiving yards on 12 receptions with a rushing and receiving touchdown. Cooper Kupp added five catches for 92 yards and a score, and Kyren Williams rushed for 87 yards and 2 TDs.
After winning the highest-scoring game of the NFL season so far, with over 900 yards of total offense combined, how will Los Angeles fare on a short week against San Francisco? Sean McVay’s club has one more win than the 49ers, but trails Seattle by one game in the NFC West standings.
QB Matthew Stafford surpassed 3,000 passing yards in a single season for the 12th time in his career, becoming the 13th-different quarterback to accomplish the feat in NFL history. pic.twitter.com/JtM4Bz94h2
— Los Angeles Rams PR (@TheLARamsPR) December 8, 2024
Niners bounce back
After dropping three-straight games to fall out of the NFC playoff picture, the 49ers bounced back on Sunday with a decisive 38-13 win over the Bears. George Kittle was uncoverable with five catches for 138 yards and Jauan Jennings made seven receptions for 90 yards and 2 TDs. Rookie running back Isaac Guerendo also did his best Christian McCaffrey impersonation, piling up 128 all-purpose yards and two scores.
Brock Purdy turned in one of his best games of the season, completing 20 of 25 pass attempts for 325 yards and two TDs. San Francisco’s victory sets up a must win Thursday nighter with a Rams team also fighting for the division crown.
San Francisco vs Los Angeles
San Francisco is a 2-point home favorite at Levi’s Stadium and the over/under is set at just 48.5-points. These two teams combined for 51 points in the Rams’ 27-24 win back in Week 3. Kyle Shanahan owns a 10-6 career record versus Sean McVay, however, he has lost two in a row against his former colleague.
Both clubs rank top ten in passing yards per game, but the 49ers have been much-better rushing the ball this season, averaging 138.9 yards per contest. Los Angeles is also allowing the fifth-most rushing yards (141.0) per game in the NFL. The Niners’ D ranks No. 3 against the pass, permitting only 182.6 yards per game.
Isaac Guerendo doesn’t seem concerned about the foot sprain he suffered today 👀 pic.twitter.com/DXFVEUSya3
— Yahoo Fantasy Sports (@YahooFantasy) December 9, 2024
Best Bet
San Francisco needs this game and is playing a Rams team that should be absolutely gassed after their offensive explosion against Buffalo. We’ll take the 49ers to cover (-2) at home and make the NFC West even more interesting heading down the stretch, with the UNDER 48.5.
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